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Epigenetics in allergy

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      EPI EEEEPEpigenetics in allergy
Epigenetics is a method by which gene expression is controlled without changes in the genetic sequence of coding genes. Along with genetic and environmental influences, epigenetics can result in changes in phenotypes resulting in disease states. Epigenetic modifications may play a role in the development of allergic and immunologic diseases. Most epigenetic changes occur as a result of DNA methylation or by modification of chromatin or histone proteins. Micro-RNAs have been discovered recently that may also effect changes in gene expression by their ability to act as inhibitors of transcription.
One of the possible mechanisms of drug-induced autoimmunity is through DNA methylation. Procainamide and hydralazine are two of several drugs that induce autoimmunity through this mechanism. By affecting gene transcription, epigenetic modification can lead to changes in activation of promoter genes, ultimately affecting important signaling pathways such as NF-B and apoptosis. MicroRNAs are 21-23 nucleotide long highly conserved sequences that bind to specific target genes leading to their inhibition, or in some cases, activation. This is an area of extensive research in many immunological and non-immunological diseases.
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EPIGENETICS IN ALLERGY

Epigenetics is a method by which gene expression is controlled without changes in the genetic sequence of coding genes. Along with genetic and environmental influences, epigenetics can result in changes in phenotypes resulting in disease states. Epigenetic modifications may play a role in the development of allergic and immunologic diseases. Most epigenetic changes occur as a result of DNA methylation or by modification of chromatin or histone proteins. Micro-RNAs have been discovered recently that may also effect changes in gene expression by their ability to act as inhibitors of transcription.
One of the possible mechanisms of drug-induced autoimmunity is through DNA methylation. Procainamide and hydralazine are two of several drugs that induce autoimmunity through this mechanism. By affecting gene transcription, epigenetic modification can lead to changes in activation of promoter genes, ultimately affecting important signaling pathways such as NF-B and apoptosis. MicroRNAs are 21-23 nucleotide long highly conserved sequences that bind to specific target genes leading to their inhibition, or in some cases, activation. This is an area of extensive research in many immunological and non-immunological diseases.

  

 

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